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The fewer the dependencies, and the less they depend on the OS, the easier the packaging.
In SOFA Statistics, dependencies, especially image-processing dependencies, made it very hard to package cross-platform.
Minimum:
All dependencies are distro / system dependencies, not pip dependencies (even if we develop in a venv).
This is to make deb packaging easy where we list system dependencies.
A couple of the key steps (there are others but you may have already done them):
sudo apt-get install build-essential python3-dev \ libwebkit2gtk-4.0-dev libtiff-dev libnotify-dev \ freeglut3-dev libsdl1.2-dev libgstreamer-plugins-base1.0-dev
And in venv (when activated):
pip install wxPython